Erratum: Corrigendum: Human genes containing polymorphic trinucleotide repeats
نویسندگان
چکیده
منابع مشابه
Trinucleotide repeats in human genome and exome
Trinucleotide repeats (TNRs) are of interest in genetics because they are used as markers for tracing genotype-phenotype relations and because they are directly involved in numerous human genetic diseases. In this study, we searched the human genome reference sequence and annotated exons (exome) for the presence of uninterrupted triplet repeat tracts composed of six or more repeated units. A li...
متن کاملTrinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.
The genome of Saccharomyces cerevisiae contains numerous unstable microsatellite sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when present in an ORF are frequently located in an intron or at the C terminus of the protein, suggesting that their instability is deleterious to gene function. DNA trinucleotide repeats (TNRs) are found at a higher-than-expected fre...
متن کاملtrinucleotide repeats ataxia
the hereditary ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. frequently, atrophy of the cerebellum occurs. the hereditary ataxias are categorized by mode of inheritance and causative gene or chromosomal locus. genetic forms of ataxia must be distinguished from t...
متن کاملTrinucleotide repeats and neurodegenerative disease.
Major insights have been attained into the molecular pathology of the trinucleotide repeat neurodegenerative diseases over the past decade. Genetic definition has allowed subclassification into translated polyglutamine diseases, which are due to CAG repeat expansions, and a more heterogeneous group in which the trinucleotide repeat remains untranslated. The polyglutamine disorders are due to a ...
متن کاملELECTRONIC LETTER Induction of instability of normal length trinucleotide repeats within human disease genes
M yotonic dystrophy type 1 (DM1) is the most frequent cause of adult muscular dystrophy. It is a progressive multisystem disorder with an incidence of 1 in 8000 newborns. Its molecular basis is an expansion of a CTG repeat in the 3’ untranslated region (UTR) of the DMPK gene on chromosome 19. Fragile X syndrome is the most common inherited cause of mental retardation. It is caused by an expansi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 1993
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng0393-273b